Recent studies have shown that the objectively measured vectorcardiographic QRS area identifies left ventricular activation delay with higher accuracy than any of the current ECG criteria. Additionally, there are various definitions for LBBB, in which each one has a different association with CRT benefit and is prone to subjective interpretation. The criteria QRS duration and left bundle branch block (LBBB) QRS morphology insufficiently detect left ventricular activation delay, which is required for benefit from CRT. Current ECG criteria in international guidelines seem to be suboptimal to select heart failure patients for CRT. DOI: 10.11909/j.issn.1671-5411.2022.01.003Ĭardiac resynchronization therapy (CRT) is a good treatment for heart failure accompanied by ventricular conduction abnormalities. Vectorcardiographic QRS area as a predictor of response to cardiac resynchronization therapy. Please cite this article as: Ghossein MA, van Stipdonk AMW, Prinzen FW, Vernooy K. András Vereckei (Semmelweis University, Budapest, Hungary). This review article is one manuscript in the Special Issue of “Non-invasive methods that may improve patient selection for cardiac resynchronization therapy”.